Season 2 of Chicago Med premiered September 22, 2016.
The show was renewed for a second season by the NBC on February 1, 2016. It will return in the Fall season, along with the sister-series. It changed the time slot from Tuesday to Thursdays, at the same hour.
- Oliver Platt as Dr. Daniel Charles
- Brian Tee as Dr. Ethan Choi
- Yaya DaCosta as Nurse April Sexton
- Colin Donnell as Dr. Connor Rhodes
- Nick Gehlfuss as Dr. Will Halstead
- Torrey DeVitto as Dr. Natalie Manning
- Rachel DiPillo as Dr. Sarah Reese
- S. Epatha Merkerson as Sharon Goodwin
- Marlyne Barrett as Maggie Lockwood
- Jeff Hephner as Jeff Clarke
- Mekia Cox as Dr. Robin Charles (New cast member!)
- Brennan Brown as Dr. Sam Abrams
- Peter Mark Kendall as Joey Thomas
- D. W. Moffett as Cornelius Rhodes
- Christina Brucato as Claire Rhodes
- Annie Potts as Helen Manning
- Susie Abromeit as Zoe Roth
- Roland Buck III as Noah Sexton
|Soul Care||Writer: Diane Frolov & Andrew Schneider||Director: Arthur W. Forney||September 22, 2016||#2x01|
|Dr. Manning and Dr. Halstead treat a pregnant patient from a car accident and are forced to perform an emergency cesarean on her. Meanwhile, Dr. Choi adjusts to his new role as Chief Emergency Resident, Dr. Reese accepts a psychiatry residency offer from Dr. Charles, and Dr. Rhodes is introduced to his new superior. Also, Dr. Manning and new medical student Jeff Clarke (guest star Jeff Hephner) connect, which infuriates Dr. Halstead.
|Win Loss||Writer: Eli Talbert & Safura Fadavi||Director: David Rodriguez||September 29, 2016||#2x02|
|Dr. Rhodes and Dr. Manning deal with two separate infant patients. Meanwhile, Dr. Halstead and Dr. Charles treat a homeless man with a vision deficiency and Dr. Choi is shadowed by a Navy corpsman as they deal with patients connected to gang violence.
|Natural History||Writer: Stephen Hootstein & Danny Weiss||Director: Michael Waxman||October 6, 2016||#2x03|
|Dr. Halstead treats Maggie's visiting sister Denise after she crashes her car due to temporary blindness. Later on, Dr. Halstead discovers that Denise is transgender and has prostate cancer. Meanwhile, Dr. Manning and fourth year medical student Jeff Clarke try to treat a patient who doesn't speak English, Dr. Reese and Dr. Charles deal with a pregnancy case that is slightly unusual, and Dr. Rhodes performs a difficult heart surgery without the consent of his attending Dr. Latham (guest star Ato Essandoh).
|Brother's Keeper||Writer: Jeff Drayer & Joseph Sousa||Director: Stephen Cragg||October 13, 2016||#2x04|
|Dr. Choi has an elderly patient who needs surgery, but his son is refusing per his father's previous instructions. Dr. Manning and Dr. Halstead are dealing with an epidemic when a virus is spread to multiple patients. Meanwhile, Dr. Reese and Dr. Charles deal with a patient who is on heroin withdrawal and has an overbearing mother who is later discovered to be his pimp, part of a sex trafficking ring. Also, Dr. Charles' daughter becomes the newest member of the epidemiology department.
|Extreme Measures||Writer: Shelley Meals & Darin Goldberg||Director: Daisy von Scherler Mayer||October 20, 2016||#2x05|
|Dr. Halstead, Dr. Shore, April, and Noah attend a marathon where they deal with a bicyclist who has been run over and are forced to perform a difficult procedure. Meanwhile, Dr. Manning treats an 8 year-old girl with sudden hearing loss and Dr. Choi treats an elderly patient (guest star Betty Buckley) who has not been taking all her medication and appears to be malnourished. Also, Sharon moves forward with her divorce.
|Alternative Medicine||Writer: Diane Frolov & Andrew Schneider||Director: Eriq La Salle||October 27, 2016||#2x06|
|Dr. Reese gets in contact with her last patient Danny, a teen involved in a sex trafficking ring and turns to Dr. Charles and Detective Erin Lindsay (guest star Sophia Bush) to help him get out of it. Meanwhile, Dr. Manning is dealt with the same young cancer patient who has taken a turn for the worse, Dr. Halstead tends to a patient with a dead bowel system and Dr. Choi deals with a young patient who does experiments on herself by swallowing little metal objects.
|Inherent Bias||Writer: Stephen Hootstein & Danny Weiss||Director: Michael Waxman||November 3, 2016||#2x07|
|Tensions arise between Sharon, Dr. Choi, and Dr. Manning when treating an old love interest of Sharon's with a fatal disease. Dr. Reese continues to help Danny, while Dr. Charles tries to prevent a surgery performed by Dr. Rhodes. Meanwhile, Dr. Halstead is asked by Noah to work for his house call app business, and April gets engaged.
|Free Will||Writer: Jeff Drayer & Joseph Sousa||Director: Charles S. Carroll||November 10, 2016||#2x08|
|Dr. Halstead and Dr. Manning meet a patient, who is in need of a kidney transplant. His brother is a match, but he is HIV positive. Meanwhile, April finds out that she is pregnant but fears her TB treatment will harm her baby. Dr. Rhodes and Dr. Robin Charles begin to flirt much to Dr. Charles' dismay. Also, Dr. Reese receives devastating news that her patient Danny has died and Dr. Choi tends to a convict patient.|