|Season 2, Episode 1|
|Air date||September 22, 2016|
|Written by|| Michael Brandt|
|Directed by||Arthur W. Forney|
Dr. Rhodes begins a fellowship in cardiothoracic surgery, only to have problems with his new boss. Also Dr. Choi is the new chief resident; Sarah receives an opportunity; and April faces her recently discovered illness.
Dr. Rhodes begins his fellowship in cardiothoracic surgery, but gets off on the wrong foot with his challenging new boss, Dr. Latham.
Dr. Choi navigates life as the new chief resident and finds the road a bit rocky, while Dr. Charles approaches Sarah with an interesting opportunity that catches her off-guard.
Elsewhere, April works to come to terms with her recently discovered illness and Dr. Manning deals with a complicated case involving a pregnant woman who was a victim in a high speed collision.
Meanwhile, Dr. Halstead takes exception to the actions of fourth-year medical student Jeff Clarke, whose past history with Dr. Manning may be a factor. Sharon Goodwin tries to pick up the pieces and move on with her life in the aftermath of Bert leaving.
- Colin Donnell as Connor Rhodes
- Nick Gehlfuss as Will Halstead
- Torrey DeVitto as Natalie Manning
- Oliver Platt as Daniel Charles
- Yaya DaCosta as April Sexton
- Brian Tee as Ethan Choi
- Rachel DiPillo as Sarah Reese
- S. Epatha Merkerson as Sharon Goodwin
- Marlyne Barrett as Maggie Lockwood